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21 juin 2021 1 21 /06 /juin /2021 18:21

SARS-CoV-2 Delta variant, also known as lineage B.1.617.2, is a variant of lineage B.1.617 of SARS-CoV-2, the virus that causes COVID-19.[1] It was first detected in India in late 2020.[2][3] The World Health Organization (WHO) named it the Delta variant on 31 May 2021.[4]

 

It has mutations in the gene encoding the SARS-CoV-2 spike protein[5] causing the substitutions T478K, P681R and L452R,[6] which are known to affect transmissibility of the virus as well as whether it can be neutralised by antibodies for previously circulating variants of the COVID-19 virus.[7] Public Health England (PHE) in May 2021 observed secondary attack rates to be 51–67% higher than the alpha variant.[8]

 

On 7 May 2021, PHE changed their classification of lineage B.1.617.2 from a variant under investigation (VUI) to a variant of concern (VOC) based on an assessment of transmissibility being at least equivalent to B.1.1.7 (Alpha variant), first identified in the UK (as the Kent variant).[9] Subsequently on 11 May 2021, the WHO also classified this lineage VOC, and said that it showed evidence of higher transmissibility and reduced neutralisation. The variant is thought to be partly responsible for India's second wave of the pandemic beginning in February 2021.[10

][11

  1.  "Confirmed cases of COVID-19 variants identified in UK". www.gov.uk. 15 April 2021. Retrieved 20 April 2021. This article contains OGL licensed text This article incorporates text published under the British Open Government Licence v3.0:
  2. ^ a b c d "Tracking of Variants". gisaid.org. GISAID. 26 April 2021. Retrieved 30 May 2021.
  3. ^ a b c "Expert reaction to cases of variant B.1.617 (the 'Indian variant') being investigated in the UK". Science Media Centre. Retrieved 20 April 2021.
  4. ^ a b "Covid: WHO renames UK and other variants with Greek letters". BBC News. 31 May 2021. Retrieved 8 June 2021.
  5. ^ a b Shang, Jian; Yushun, Wan; Lou, Chuming; Ye, Gang; Geng, Qibin; Auerbach, Ashley; Fang, Li (2020). "Cell entry mechanisms of SARS-CoV-2". Proceedings of the National Academy of Sciences. 117 (21): 11727–11734. doi:10.1073/pnas.2003138117. PMC 7260975. PMID 32376634.
  6. ^ "expert reaction to VUI-21APR-02/B.1.617.2 being classified by PHE as a variant of concern". sciencemediacentre.org. 7 May 2021. Retrieved 18 June 2021.
  7. ^ a b c d Starr, Tyler N.; Greaney, Allison J.; Dingens, Adam S.; Bloom, Jesse D. (April 2021). "Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016". Cell Reports Medicine. 2 (4): 100255. doi:10.1016/j.xcrm.2021.100255. PMC 8020059. PMID 33842902.
  8. ^ "SARS-CoV-2 variants of concern and variants under investigation in England" (PDF). 27 May 2021. Retrieved 18 June 2021. This article contains OGL licensed text This article incorporates text published under the British Open Government Licence v3.0:
  9. ^ "Confirmed cases of COVID-19 variants identified in UK". www.gov.uk. 7 May 2021. Archived from the original on 7 May 2021. Retrieved 7 May 2021. This article contains OGL licensed text This article incorporates text published under the British Open Government Licence v3.0:
  10. ^ WHO labels a Covid strain in India as a 'variant of concern' — here's what we know, CNBC, 11 May 2021.
  11. ^ "WHO says India Covid variant of 'global concern'", BBC News, 11 May 2021.
  12. ^ "India's second COVID-19 wave", The Wire Science, 22 April 2021.
  13. ^ "Genomic epidemiology of novel coronavirus - Global subsampling (Filtered to B.1.617)". nextstrain.org. Retrieved 5 May 2021.
  14. ^ "SARS-CoV-2 Variant Classifications and Definitions". cdc.gov. Centers for Disease Control and Prevention. 15 June 2021. Retrieved 18 June2.
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