Wnt/beta-catenin signaling

18.02.2014

Cytokine Growth Factor Rev. 2000 Dec;11(4):273-82.

Wnt/beta-catenin signaling.

Abstract

The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Recent studies have revealed that a number of proteins such as, the tumor suppressor APC and Axin are involved in the regulation of the Wntsignaling pathway. Furthermore, mutations in APC or beta-catenin have been found to be responsible for the genesis of human cancers.

PMID:
: 10959075
: [PubMed - indexed for MEDLINE]