REVIEW part I

WHOLE BLOOD AND YOUNG PLASMA.

CONCLUSIONS AND SCIENTIFIC PROPOSALS OF THE REVISIONS.

Rodolfo Sixto Negri-Biochemist University of Buenos Aires-Lic. in Biochemist-Spain. Master University in Biology Molecular and Biomedicine-University País Vasco-Spain.

ADVANCES IN REGENERATIVE MEDICINE, MAKE MORE EXPECTANCES THE TREATMENT OF AGING AT NEUROLOGICAL LEVEL, SUCH AS NEURODEGENRATIVE DISEASES, SENIL DEMENTIA (ALZHEIMER), NOT BEING THE DISEASE IN YES, BUT YOUR OWN AGING AT ALL LEVELS: BRAIN, CARMEL, SKELETAL MUSCLE, SKIN, BONE. ... ..WITH CHANGES IN ITS EPIGENOMA, CELLULAR REPROGRAMMING, ACTIVATION OF GENES, INCREASE IN THE NUMBER OF SPECIFIC RECEIVERS AND ITS ACTIVATION, INCREASE IN THE LEVELS OF FACTORS OF THE BLOOD, GIVING AS A RESULT THE REVERSIBILITY OF AGING, YOUNG TISSUE FORMATION AND HEALTHY, ELEMENTS NECESSARY AND PROVIDED WITH YOUNG BLOOD.

Scientists clearly demonstrate rejuvenating in different organs, brain, heart, muscle, bone, pancreas, liver ... (Tony Wyss-Coray et al., 2015, Saul Villeda et al., 2011, 2014, Katsimpardi et al., 2014, Bath et al. 2015, Conboy et al 2005, Sinka et al 2014, Lofredo et al, 2013, Salpeter et al 2013.), proteins, enzymes, membrane receptors, decrease their concentration throughout our lives, even some disappear from about 20 years, according to genetics, exert their action, activate genes, inducing cell reprogramming, transforming adult cells into pluripotent cells similar to embryonic cells, change in their epigenome (acetylation of Histone H3K4Me3 ... .H3K27Me3, generally associated with the expression of genes), neuroprotection of the functions of the Histone deacetylase SIRT6, degrading the toxic protein TAU, Kaluski et al., 2017.

The cell can modify the sensitivity of the receptor, for example by phosphorylation, also by varying the number of receptors that can modify the total signaling strength inside the cell.

Nuclear or cytoplasmic receptors are soluble proteins located in the cytoplasm or cell After a transfusion with young blood or plasma, multiple mechanisms of action at the molecular level are initiated; due to the increase in the concentration of certain hormones, proteins and enzymes. Specific receptors and genes that induce cell reprogramming are activated, generating healthy tissue. DNA repairs itself more quickly. New proteins are generated by activation of certain genes, which were inactive.

In turn there are mechanisms of cellular, extrinsic and intrinsic apoptosis, (Brenner and Mak et al., 2009, Declercq, Vanden Bergue and Vandenabeele, et al., 2009).

New cells and healthy tissue are generated, modifying organs of a more rejuvenated appearance, (Tony Wyss-Coray et al., 2015, Saul Villeda et al., 2011, 2014, Katsimpardi et al., 2014, Bath et al., 2015, Conboy et al. al., 2005, Sinka et al., 2014, Lofredo et al, 2013, Salpeter et al., 2013).

It also activates epigenetic regulatory mechanisms, acetylation, deacetylation ... (Albaugh, Arnold, and Denu, et al., 2011), methylation, demethylation ... of histones (Kooistra and Helin, et al., 2012), and regulation of chromatin (Binda et al., 2013; Laue and Frizzell, et al., 2012).

There is an increase in the concentration of certain proteins [P], hormones, growth factors, cytokines, ... enzymes, etc.) that are incorporated in young blood, there are specific ligands, which act by binding to specific receptors, through molecular mechanisms that fulfill several parameters, as joining forces:

Kd = [P] x [R]          [P] = concentration of the protein

         ---------            [R] = concentration or number of receivers

           [PR]              [PR] = Protein-Receptor binding

The concentration of circulating proteins is the main point of signal strength.