Receptores de ACE2 se han demostrado para ser el punto de entrada en las células humanas para algunos coronavirus, incluyendo el SARS virus [10] . Varios estudios han identificado que el punto de entrada es el mismo para SARS-CoV-2 , [11] el virus que causa COVID-19 [12] [13] [14] [15] .
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM (agosto de 2005). "Un papel crucial de la enzima convertidora de angiotensina 2 (ACE2) en la lesión pulmonar inducida por coronavirus SARS". Medicina de la naturaleza . 11 (8): 875–9. doi : 10.1038 / nm1267 . PMID 16007097 .
^Zhou P, Yang X (03-02-2020). "Un brote de neumonía asociado con un nuevo coronavirus de probable origen de murciélago". Naturaleza . doi : 10.1038 / s41586-020-2012-7 . PMID 32015507 .
^Xintian, Xu; Chen, Ping (2020). "Evolución del nuevo coronavirus a partir del brote en curso de Wuhan y modelado de su proteína de pico para el riesgo de transmisión humana". Ciencia China Life Sciences . doi : 10.1007 / s11427-020-1637-5 . PMID 32009228 .
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