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Remdesivir

Remdesivir (código de desarrollo GS-5734) es un medicamento antiviral, un nuevo profármaco análogo de nucleótido. Fue desarrollado por Gilead Sciences como un tratamiento para la enfermedad del virus del Ébola y las infecciones causadas por el virus de Marburgo, aunque posteriormente también se descubrió que muestra una actividad antiviral razonable contra otro virus, entre ellos el virus sincitial respiratorio, el virus Junín, el virus de la fiebre de Lassa y posiblemente el coronavirus MERS. Remdesivir fue rápidamente impulsado a través de ensayos clínicos debido a la crisis epidémica del virus del Ébola en África Occidental 2013-2016, y finalmente se usó en al menos un paciente humano a pesar de su etapa de desarrollo temprano en ese momento. Los resultados preliminares fueron prometedores y se usó en el entorno de emergencia para el Brote de Ébola de Kivu 2018-20 junto con otros ensayos clínicos, hasta agosto de 2019, cuando los funcionarios de salud congoleños anunciaron que no era efectivo en comparación con otros tratamientos como el mAb114 y el producido por Regeneron REGN3470-3471-3479 (también llamado REGN-EB3). [1] [2][3][4][5][6][7]​ También puede ser utilizada para proteger contra las infecciones causadas por el virus Nipah y Hendra como así como los coronavirus como el SARS, y posiblemente en las infecciones de 2019-nCoV. [8]Remdesivir (código de desarrollo GS-5734) es un medicamento antiviral, un nuevo profármaco análogo de nucleótido. Fue desarrollado por Gilead Sciences como un tratamiento para la enfermedad del virus del Ébola y las infecciones causadas por el virus de Marburgo, aunque posteriormente también se descubrió que muestra una actividad antiviral razonable contra otro virus, entre ellos el virus sincitial respiratorio, el virus Junín, el virus de la fiebre de Lassa y posiblemente el coronavirus MERS. Remdesivir fue rápidamente impulsado a través de ensayos clínicos debido a la crisis epidémica del virus del Ébola en África Occidental 2013-2016, y finalmente se usó en al menos un paciente humano a pesar de su etapa de desarrollo temprano en ese momento. Los resultados preliminares fueron prometedores y se usó en el entorno de emergencia para el Brote de Ébola de Kivu 2018-20 junto con otros ensayos clínicos, hasta agosto de 2019, cuando los funcionarios de salud congoleños anunciaron que no era efectivo en comparación con otros tratamientos como el mAb114.

 

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