Information scientifique avancée
/image%2F1572350%2F20180904%2Fob_6196b4_t-cell-receptor-and-cd3-complex.jpg)
Receptor de células T y complejo CD3 Los linfocitos son uno de los cinco tipos de glóbulos blancos o leucocitos que circulan en la sangre. Aunque los linfocitos maduros se parecen mucho, son extraordinariamente diversos en sus funciones. Los linfocitos...
Lire la suite/image%2F1572350%2F20180902%2Fob_e4ac0e_gr3.jpg)
Introduction The inexorable tolls of aging are evident in almost all living beings. From the onset of reproductive maturity, organismal aging is generally characterized by a decline in fecundity, an increased susceptibility to disease and tissue dysfunction,...
Lire la suite/image%2F1572350%2F20180901%2Fob_52d585_nature20411-f1-1.jpg)
Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia,...
Lire la suite/image%2F1572350%2F20180901%2Fob_a7fa14_gr1.jpg)
Young at Heart Leslie A. Leinw and Brooke C. Harrison Within the context of an increasingly aged population, the healthcare costs associated with aging-related heart failure represent a significant healthcare burden. Diastolic heart failure, characterized...
Lire la suiteSox10 labeling in metastatic breast carcinomas. Nelson ER 1, Sharma R 1, Argani P 2, Cimino-Mathews A 3. Author information Abstract Sox10 labeling by immunohistochemistry has been primarily reported in tumors of neural crest origin, such as nerve sheath...
Lire la suite/image%2F1572350%2F20180830%2Fob_f365ae_583707512d0a8.jpg)
Cell reprogramming earned its discoverer, Shinya Yamanaka, the Nobel Prize and opened the door to regenerative medicine. This technique, based on introducing a combination of four genes known as OSKM (for the initials of the genes, OCT4, SOX2, KLF4 and...
Lire la suite/image%2F1572350%2F20180830%2Fob_ec3af2_fx1-lrg.jpg)
SIRT6 loss causes pathological changes in behavior, DNA damage, apoptosis, and Tau Tau is stabilized and hyperphosphorylated by GSK3 in the absence of SIRT6 Phenotypes in SIRT6 knockout cells can be rescued by GSK3 or ATM inhibition Patients with Alzheimer’s...
Lire la suiteGSK3 is a key regulator in several physiological processes, such as cell cycle, oncogenesis and apoptosis in neuronal cells and VSMC (Vascular Smooth Muscle Cells) during hypoxia (Ref.8). Increased cAMP levels promote survival of neuronal cells by inactivating...
Lire la suite/image%2F1572350%2F20180830%2Fob_92b6ad_gsk3-signaling.jpg)
GSK3 (Glycogen Synthase Kinase-3) is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.Identified originally as a regulator of glycogen metabolism, GSK3 acts as a downstream regulatory switch for numerous...
Lire la suite/image%2F1572350%2F20180830%2Fob_9872c8_alzheimers-disease-pathway.jpg)
Despite decades of intense research, therapeutics for Alzheimer's disease (AD) are still limited to symptomatic treatments that possess only short-term efficacy. There are currently four main mechanisms of action that are being actively developed in AD...
Lire la suite