Information scientifique avancée
Felicitaciones también al hospital Cruces de Bilbao, utilizando una crema con Bromelina para quemaduras para que la Bromelina desintegre las crostas de piel quemada y muerta, evitando cirugías en los quemados. La bromelina, sustancia derivada del tallo...
The Chemokine receptor CXCR4 is a 352 amino acid rhodopsin-like GPCR and selectively binds the CXC chemokine Stromal Cell-Derived Factor 1 (SDF-1) also known as CXCL12. This receptor has been described as undergoing dimerization after binding to CXCL12...
Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia,...
Young at Heart Leslie A. Leinw and Brooke C. Harrison Within the context of an increasingly aged population, the healthcare costs associated with aging-related heart failure represent a significant healthcare burden. Diastolic heart failure, characterized...
Cell reprogramming earned its discoverer, Shinya Yamanaka, the Nobel Prize and opened the door to regenerative medicine. This technique, based on introducing a combination of four genes known as OSKM (for the initials of the genes, OCT4, SOX2, KLF4 and...
GSK3 (Glycogen Synthase Kinase-3) is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.Identified originally as a regulator of glycogen metabolism, GSK3 acts as a downstream regulatory switch for numerous...
Despite decades of intense research, therapeutics for Alzheimer's disease (AD) are still limited to symptomatic treatments that possess only short-term efficacy. There are currently four main mechanisms of action that are being actively developed in AD...
Oxidative stress/Hypoxia is induced by a wide range of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), oxygen shortage, etc. Generation of ROS (Reactive Oxygen Species) is characteristic feature of such stress conditions....
MS (Multiple Sclerosis) is an inflammatory and demyelinating disease of the CNS (Central Nervous System). MS is classified according to its clinical course into several categories: benign, RR (Relapsing-Remitting, the most common variant), PR (Progressive-Relapsing),...
Within a normal tissue, multiple anti-proliferative signals operate to maintain cellular quiescence and tissue homeostasis. Incipient cancer cells evade these anti-proliferative signals in order to prosper. Cancer cells also switch to different types,...
References Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling. Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2). Contribution of...
Akt Signaling Akt is an evolutionarily conserved serine/threonine kinase involved in a wide variety of cellular functions, including proliferation, cell survival, differentiation, glucose mobilization, homeostasis, cell migration, and apoptosis. Three...
Binding of fibroblast growth factor (FGF) to fibroblast growth factor receptor (FGFR), binding of epidermal growth factor (EGF) and heparin-binding (HB)-EGF to epidermal growth factor receptor (EGFR) and binding of platelet-derived growth factor (PDGF)...
.................... TAK1 and the SMAD pathways, activated by BMPs , act in parallel to promote Cardiogenesis by activating several transcription factors like ATF2 (Activating Transcription Factor-2), NKX2.5 and GATA4 . ATF2 is critical for Cardiomyocyte...
................ Proteins of the WNT family are also known regulators of Cardiomyogenesis. WNTs can bind to Fz (Frizzled) receptors on target cells to activate different signaling pathways. Activation of the canonical pathway leads to stabilization of...
Factors Promoting Cardiogenesis in Vertebrates Heart is the first organ to form and function in the Embryo, and all subsequent events in the life of the organism depend on the Hearts ability to match its output with the organisms demands for Oxygen and...
Embryonic Cell Differentiation into Cardiac Lineages Stem Cells are undifferentiated cells with broad developmental potential. They are able to generate various specialized cell types and, in addition, have the capacity to self-renew and thus to produce...
La histona desacetilasa SIRT6 promueve la reparación del ADN, pero su actividad disminuye con la edad con una acumulación concomitante de daño en el ADN. Además, los ratones knockout para SIRT6 exhiben un fenotipo de envejecimiento acelerado y mueren...
Immunotherapies that target CD1d-restricted invariant NKT (iNKT) cells can prevent tumor growth in murine models but trials in humans have shown limited clinical efficacy. Here, we show that iNKT cells are depleted from blood and bronchial lavage samples...
Reprogramming of differentiated cells into pluripotent cells can occur in vivo, but the mechanisms involved remain to be elucidated. Senescence is a cellular response to damage, characterized by abundant production of cytokines and other secreted factors...
Las sirtuinas son desacetilasas dependientes de NAD que están altamente conservadas de bacterias a humanas y se demostró que SIR2 extiende la vida útil de las levaduras en ciernes ( Imai et al., 2000 ; Kaeberlein et al., 1999 ). Desde entonces, se ha...
Alzheimer, se trata el envejecimiento del ser humano a nivel molecular, con cambios en su epigenoma, aportando factores que se han perdido con los años, activando genes que inducen la reprogramación celular, con la consecuente transformación de celulas...
Genes que inducen reprogramación La generación de células iPS depende de que los genes adecuados se usen para la inducción de la reprogramación. Hasta ahora se han identificado los Oct-3/4 y varios miembros de la familia Sox (Sox1, Sox2, Sox3, Sox15)...
Las bacterias pueden incorporar ADN externo en otras circunstancias e incluso pueden tomar ADN dañado de su medio. 10 Las secuencias repetidas que luego se conocerían como CRISPR fueron identificadas por primera vez por un grupo de científicos japoneses...
Los CRISPR (en inglés: clustered regularly interspaced short palindromic repeats, en español repeticiones palindrómicas cortas agrupadas y regularmente interespaciadas 2 ) son loci de ADN que contienen repeticiones cortas de secuencias de bases. Tras...
